What’s New on the Swine Flu Vaccine Front
Jun 8 at 7:07pm by Aileen
The World Health Organization Epidemic and Pandemic Alert and Response Update as of June 5 is maintaining the pandemic alert at Level 5 for the time being, but seeking input from members for fine-tuning the system to account for virulence and other factors not currently considered. The system should be more receptive to the severity of outbreaks in different countries or regions to better characterize to the public and public health officials worldwide to monitor the actual situation in their areas in order to avoid excessive response or not enough response.
In the meantime, the mortality rate of this flu, while initially high in the Mexico City area, has fallen overall to around 2% or less, in line with annual deaths during flu season. Those who contract the virus are still those generally considered to be in the healthiest range of the population. On the vaccine development front there have been several developments since the 2009 Swine Flu epidemic began:
On April 29 vaccine researchers at St. Louis University announced that they’d accomplished the first step in developing a universal vaccine against pandemic influenza. To accomplish this the researchers used proteins (engineered a ‘bug’ that produced said proteins from genetic sequences coding for them) from both A and B influenza strains. The vaccine introduces those proteins so the body can engineer antibodies specific to them. More testing is needed, they say, before the vaccine is ready for prime time.
On May 1 Juergen A. Richt, a pathobiologist at Kansas State University’s college of veterinary medicine released findings that the current lineage of H1N1 Swine Flu is a descendant of the 1918 strain that killed more than 20 million people worldwide. For the study Richt and colleagues from Canada, USDA and Mount Sinai engineered their ‘bug’ in a biosafety-level-4 lab (like the one at UT-Austin) at the National Centre for Foreign Animal Disease in Canada using elements from both the 1918 virus and a 1930 descendent of that virus.
On May 22 researchers at the University of Pittsburgh’s Center for Vaccine Research announced that they’d evoked a robust immune response with a vaccine made of virus-like particles [VLPs], which are just the protein coats of actual viruses without any genes inside. This approach, which like other approaches involves genetic manipulation to produce the “hollow” virus shells, may work better than attenuated virus vaccines. The new vaccine for Human Papilloma Virus is a VLP.
And finally, on June 4 Genetic Engineering and Biotechnology News reported that scientists around the world are accelerating efforts to develop an effective vaccine against the current Chimera strain. This is ‘news’ in the GE/biotech community because genetic manipulation is standard operating procedure in the development of influenza vaccines, of any type – live, attenuated, killed and dissociated or VLP. Step #1 is to engineer your Chimera.
No matter how the Chimera came to be, Bellerophon is engineered very much on purpose. I personally like the idea of the VLP vaccine, as it ONLY has coat proteins and it excites a more robust immune response to those than to dissociated coat proteins. The robust response is to the form of the viral shell. Even better, if these beasties get out in an ‘oops’ it won’t kill anybody – it’ll just immunize ‘em. Let’s all hope one of these is available come September.
Great Green Gobs of Greasy, Glowing… Marmosets?
May 29 at 5:05pm by Aileen
Green Glowing Monkey Paws
Well, I’ve got to admit this much-touted development in the world of medical research took me somewhat by surprise. Mostly because it caused me to stop eating my grilled cheese sandwich mid-bite to wonder “Huh? Why in the world would they do that?”
Seems this week’s Nature is reporting that researchers in Japan have managed to genetically engineer the green fluorescent protein gene into primates – specifically marmosets. Yes, these endearingly cute little monkeys have been engineered to express the gene in their hair roots, skin and blood, all of which glow green under UV light sources.
Now, I can understand why tropical fish aficionados might want several tetras of each color (they’ve got several now) in their aquarium to impress friends, neighbors and potential mates, but glowing green marmosets? You’ve got to have a primate license to own any kind of monkey or ape! The researchers responsible for this development say that this feat of genetic engineering could lead to monkeys being bred with genetic changes that would make them good animal models of human diseases.
Barack Obama Answers the Science Questions
Aug 30 at 11:11pm by Aileen
Democratic Presidential candidate Barack Obama has submitted his Answers to the Top 14 Science Questions facing America. Drawing on the expertise of a squadron of science, economic, foreign policy and educational advisors that includes several committed Nobel Laureates, many will be happy to get the religious and political ideology out of the way and really start addressing these issues.
Please go to the ScienceDebate 2008 website, take a hard look at Obama’s answers for our future, and don’t forget to drop the crew a dime (or ten) on your way out. These folks have been hard at it since November of last year, and have gathered some very impressive institutional support. The future is important to all of us – and our children – and the future needs the very best science we can possibly field to meet it head-on.
Fill ‘er Up!
Jun 9 at 5:05pm by Aileen
…with Bug Juice, please.
When I started college in the late 1960s in Oklahoma, I could buy gas for my Volkswagon Bug for 19.9¢ a gallon. That’s 5 gallons for a dollar, enough to drive home to visit the folks, drive around town to see friends, and get back to college without having to stop at a gas station. This past weekend I drove our little pickup to Gatlinburg, Tennessee to see an old Navy buddy, a round trip equivalent to that past Oklahoma weekend trek. Gas for the journey cost us right around $50. A dollar’s worth won’t get me to the grocery store and back any more, and it doesn’t look like the price is ever going to come down.
The going price per barrel of petroleum is pushing $150 hard and will probably go over $200 before the end of the year. Diesel fuel is a dollar more expensive than gasoline, and the price of everything grown on a farm and transported by ship, train or truck must go up accordingly.
The good news – or, at least the hopeful news is that progress is being made in deciding what replacement fuels we should be developing. Most people are skeptical of corn-based ethanol and the diversion of food crops as well as crop land to biofuels. And while new techniques can make biofuels from native vegetation like switchgrass or even algae, the fact is that plants aren’t very efficient at converting solar energy into the biomass required.
Biotech researchers are now turning to engineered microorganisms as both helpers in turning biomass into fuels and as fuel themselves – photosynthetic bacteria that can capture sunlight energy 100 times more efficiently than plants – that can be grown in massive amounts without competing for cropland.
It does appear that the time has finally come when human civilization must change its ways, the only questions being how much it’s going to hurt regular people and which nations and/or multinational corporations will corner the markets. Perhaps biotechnology can be put to good use creating new fuel sources instead of turning staple foods into pesticides. That would be a positive change of focus, help get the tarnish of public resistance off the biotech bus, and maybe even save the planet.
But you and I will probably be paying at least $5 a gallon to fill our tanks, no matter what kind of fuels are developed. Just something we’ll have to get used to.
Links:
New Source for Biofuels Discovered
Harnessing Microbes to Meet Future Energy Needs
Are microbes the answer to the energy crisis?
Biotech Propaganda Meets Scientific Reality
Apr 29 at 6:06pm by Aileen
In its mad bid to privatize and control the world’s agriculture and food supply with its patented biotech seeds and cushy revolving door within governmental regulatory agencies, Monsanto cannot be very happy with a recent Soil Association report that shows GM crops decrease yields, whether it’s cotton or soybeans or corn.
As reported in The Washington Post, the biotech industry immediately released yet another bought-and-paid-for report claiming totally opposite conclusions (some things don’t change just because the science is against you). The Soil Association report took a serious look at reality, something quite refreshing in this field. The material included among other citations:
• a 2007 study from Kansas State University that showed Roundup Ready soy has suffered “yield drag” since it was introduced, producing an average of 9-25% less per acre than conventional soy.
• a rigorous independent US study under controlled conditions demonstrating that Bt corn yields up to 12% less than conventional corn.
• an article in Nature Biotechnology reporting that Bt cotton doesn’t even express the engineered pesticide in 25% of some varieties sold under exclusive license.
The crop failures and their tragic effects on farmers in poorer nations may be a product of the technology itself according to some analysts.
Read the rest of this entry »
Ebola Vaccines Successful in Primates
Mar 31 at 8:08pm by Aileen
Soon to enter human trials
The US Centers for Disease Control and Prevention is reporting this week that researchers from the US and Canada have successfully tested several vaccines for Ebola in primates, and are now seeking to modify them for human use.
This is a significant development not because Ebola in its natural habitat is such a grave danger to humanity, but because it’s got a 90% fatality rate and thus represents a threat to humanity as a bioweapon. While Ebola is not easily spread (direct contact with bodily fluids of an infected person or animal is required), officials have long been concerned that it could be “weaponized” – as has been done with anthrax, for instance – into a form that will be easily infective. There have been just over 1500 documented cases of Ebola in humans, and so far it does not seem to have been used as a bioweapon.
The Federation of American Scientists maintains an Ebola Fact Sheet indicating that the Soviet Union probably investigated weaponizing Ebola. There have been three reported incidents of researchers being infected after being stuck with contaminated syringes. Those in England and the U.S. recovered, one in Russia died. There is no effective treatment for the disease, and while the current research is hopeful, there is no vaccine to prevent it.
The biosafety threat level for Ebola is 4, a rating it shares with the 18 other hemorrhagic fevers it is akin to. Because the dead virus does not produce an effective immune response, researchers have been trying several different recombinant DNA techniques. The latest, most effective candidates are soon to be tested on humans. It is hoped that if the testing proves successful, the techniques will be as useful in developing vaccines for other hemorrhagic fever viruses, HIV and avian influenza.
Links:
Vaccine for Ebola Virus Successful in Primates
Ebola Fact Sheet
Attack of the Killer Bee… er, Bee Killer
Feb 7 at 9:09pm by Aileen
Bloomberg reported today that whatever killed the bees last year is back again this year, threatening some $15 billion worth of crops that depend on bees for pollination.
Honeybee Deaths Resume in U.S. Hives cites the USDA’s top honeybee researcher as saying that the effects of continuing Colony Collapse Disorder should become apparent by the end of the month, when growers will see how effective the pollination of California’s huge almond crop has been.
“Colony Collapse Disorder” is a fancy name for an unknown entity, since no one has been able to figure out what’s killing the bees. The bees that have been found (most just disappear) have devastated immune systems, but still no one knows what, exactly, they’re dying of. The US lost a quarter of all hives in 2006 and 2007, and may lose that much or more this year despite the importation of Australian bees to replenish the supply.
Some experts think a virus is responsible, others say that any illness could easily kill bees whose immune systems have been seriously compromised, so it’s whatever is attacking immune systems that is the real killer. Dead bees that remain in the hives are infected with a host of pathogens – “every known bee virus” according to UK’s The Independent newspaper – not just one. Some bees were carrying five or six viruses at the same time, along with fungal infections. That is more likely to be a pesticide or herbicide being used on the crops or on neighboring crops, though others claim it’s just stress.
Some experts in Europe, where Colony Collapse Disorder is hitting Germany hard, are concerned about pollen from genetically modified crops, many of which contain microbial toxins – pesticide – in every cell. If that turns out to be the issue, farmers may end up with restrictions on growing genetically engineered crops in regions where bee pollinated crops are also grown. Research demonstrating that the transgenes in GE crops have migrated to wild plants may make restrictions a moot point, however, and we’ll just have to come up with another way to pollinate crops.
Links:
Honeybee Deaths Resume in U.S. Hives
European Bees Also Taking a Nosedive – Perhaps GM Crops?
Genetically Engineered Corn Endangers Aquatic Ecosystems
Nov 15 at 7:07pm by Aileen
The Chicago Tribune reports this week that scientists at Loyola University have established that the pollen, leaves and other plant parts of corn engineered to kill the European corn borer with Bt toxins could endanger the American midwest’s aquatic ecosystems when washed into nearby streams.
When eaten by aquatic insects called caddisflies, the Bt toxin stunts growth and increases mortality. These insects are food for fish and amphibians in the ecosystem. The scientists reportedly ‘feel’ that such unanticipated effects of GE technology need to be investigated, but of course the EPA and USDA (and Monsanto) don’t feel that way at all.
It might be difficult to separate the effects of GE plant wastes from the general toxic overload caused by modern agribusiness mega-farming practices, which also cause death and deformity among aquatic life forms and amphibians in midwestern ecosystems. And while consumers at home and abroad have made it known that they do not wish to consume genetically engineered pesticides disguised as food, the new market for corn as ethanol fodder makes it unlikely that GM corn is going to be phased out any time soon.
Related Links:
Older farmers less likely to plant Bt corn
GM corn might affect ecosystems
Eat to Live: 1 million against GM food
Eat to Live: Agriculture inspectors chided
Global Warming, Biodiversity and Biofuels
Oct 12 at 5:05pm by Aileen
The dramatic breakup of the northern ice sheet has tended to confirm global warming, and there are other indications that things are worse than we thought. Turns out that North America’s Northernmost Lake is showing signs of climate change too.
An international research team reports that a core sample of lake bed sediment indicates a drastic change in algae and diatom concentrations in the lake over the last 200 years, but not in the 8,000 years prior – when the lake was permanently frozen. This tends to support the hypothesis that human industrialization has contributed to the warming.
Even if we stopped releasing greenhouse gases today we’d still have to deal with the effects of climate change, and this has been a concern for important ecosystems’ stability. Good news is that researchers have discovered Forests of Endangered Tropical Kelp surviving just fine in the deep waters off the Galapagos Islands.
Little Hoods, Little Goods, Little Doo-Dads from the Woods…
Sep 7 at 3:03pm by Aileen
(With apologies to Zappa/Beefheart and Poofter’s Froth Wyoming)
In the science news this week reports run the gambit of science and technology, including biofuels, nanotechnology, genes and genomes, evolution, and bizarre animal behavior.
Nanotechnology
Single-Atom Data Storage, Single-Molecule Switching
In the quest for ever smaller, ever more useful computers and other devices, IBM reported this week that its researchers have made significant progress in understanding the magnetic properties of atoms, which opens the door to computational and data storage devices that will have practical applications even beyond current AI dreams of quantum computers.
The researchers unveiled the first single-molecule switch, which operates flawlessly and does not disrupt the molecule’s outer frame. They used IBM’s scanning tunneling microscope [STM] to manipulate single iron atoms, arranging them with precision on a prepared copper surface. Two papers on the subject have been published in the Sept. 5 issue of the journal Science.
RECENT COMMENTS