New Hope for Alzheimer’s Patients?
Jul 21 at 6:06pm by Aileen
USPS Alzheimer’s Stamp
Rapid Alzheimer’s Improvement After New Immune-based Treatment
The open access journal BMC Neurology published research this week detailing some amazing results from the use of the anti-tumor necrosis factor-alpha [TNF-alpha] drug to treat symptoms of Alzheimer’s Disease from a novel immune system approach. Researchers documented improvement in language function within minutes of administering the drug, tending to confirm preliminary evidence that disrupted neural communication in Alzheimer’s patients may be reversible.
This is a very hopeful development, as are results from clinical drug trials in recent years slowing the progression of the disease in elderly patients as well as ongoing research into substances that may help clear the beta amyloid placques in the brain tissue, characteristic of the disease. As the Baby Boomer generation ages, it is estimated that up to 10 million of them will get this awful disease.
Some doctors are expressing concern about unduly raising hopes in patients and their families on these very early findings. Dr. Sam Gandy, chairman of the Alzheimer’s Association’s medical and science council, has expressed suspicion due to the private nature of the research because the lead researcher has a financial interest in the drug. It is hoped that other laboratories and scientists will be able to duplicate the results, but that more rigorous clinical work remains to be done.
UCLA associate professor of neurology John Ringman and colleagues have reported in the journal Neurology that there may be a way to detect Alzheimer’s even before symptoms appear by measuring the level of certain proteins in the blood and spinal fluid. These proteins are potentially useful biomarkers to identify and track progression of the disease before the patient shows any signs of deteriorating mental acuity.
The amount of suffering for the families of those 10 million people could be reduced drastically if there were effective treatments, so there is a good deal of public and private research ongoing. Hopefully when the Boomers reach an age where they have ready access to medical care via Medicare, diagnosis and treatment will be available to them.
Addicted To Your Baby’s Smile
Jul 8 at 3:03pm by Aileen
Most parents know very well how heart-warming their baby’s smile can be, to the point where just doing something silly to get that smile-fix becomes a regular way of life. I’ve heard all sorts of weird philosophies about baby smiles - “it’s just gas,” “they’ve got the intelligence of rats,” etc., etc., things that only non-parents would ever think of.
So it’s cool that researchers at the Baylor College of Medicine have finally demonstrated the addictive quality of baby smiles, as reported recently in the journal Pediatrics. Turns out that baby smiles actually ‘light up’ the reward centers of the human brain, particularly in Moms - it’s what they call a “Natural High.”
Baby’s Smile Is A Natural High
The researchers hope their work will help scientists understand the unique mother-infant bonding so critical for proper child development (and mothers’ mental health).
No doubt this is fine research, and it’s gratifying to know that science is actually looking at phenomena they could have known all along if they’d just asked a Mom. Oh, well. That famous scientific skepticism needs physical ‘proof’ of physical phenomena before it will believe anything most regular people know from direct empirical experience. Maybe they’ll now come up with a pill that mimics this high, which will no doubt be a big item on the black market for pharmaceuticals…
Send In The Clowns! …Humor as Coping Mechanism
Jun 19 at 4:04pm by Aileen
Way back in 2005 researchers at Texas A&M determined that humor - an appreciation of the absurd hilarity of life - can significantly increase Hope, and that hopefulness helps people cope with stresses in daily life and during illnesses as well.
In January of this year a communications professor at Canisius College in Buffalo, New York, demonstrated that in a medical setting, laughter is the best medicine. Humor helps both the doctors and the patients cope. The finding was extended to the workplace and to educational situations as well, eventually reaching the conclusion that regardless of the content, humor seems to be beneficial and productive. It helps to get the point across in almost any situation.
Then on June 12, 2008 Alastaire Clarke published his Pattern Recognition Theory of Humor, which purportedly explains the reason that humor is common to all human societies. In Humor Shown to be Fundamental to Our Success as a Species, Clarke claims that humor is fundamantal to the evolution of human beings, and continues to be important in the cognitive development of infants and children.
Alas, Clarke’s Pattern Recognition Theory can’t tell us what’s funny or why, so it probably won’t be used by comedy writers or clowns to formulate their skits any time soon. And while humor can progress from basic slapstick to childish jokes to ridicule to satire, he does not attempt to explain why slapstick still makes us laugh even if we’ve progressed all the way to dry British satire. A clown would have a handy explanation for that, but I don’t think Clarke asked one. Oh, well.
The articles do make a strong case for the survival value of humor to human beings, and that may be all we really need to know about it.
Links:
Humor Can Increase Hope, Research Shows
Laughter is the Best Medicine
More Cool, Mind-Blowing Facts!
Jun 6 at 3:03pm by Aileen
Here are some more strange (and very disturbing) facts about the human body, from Vicki over at the One Big Health Nut blog…
• Nearly 50% of the bacteria in your body (and humans harbor 3 times more bacterial cells than human cells) live on the surface of your tongue, which (by the way) is the strongest muscle in your body. Probably a good reason why Mommy-Kisses work better than Mommy-Licks on boo-boos.
• The incidence of immune system diseases has increased more than 200% in the last five years. Yikes! Is that environmental?
• By the time a person is 35 years old, s/he begins losing about 7,000 brain cells a day which are never replaced. Whoa. I’d say something profound about that, but I forgot what the subject was…
• A moderate sunburn damages blood vessels in the skin so seriously that it takes between four and fifteen months for them to heal. The reason I keep SPF 50 on hand all summer.
• Right-handed people live an average of nine years longer than left-handed people. Need I remind readers that correlation does NOT equal causation?
Go on over to One Big Health Nut and read the rest for yourself!
Surprise! Human Babies Should Drink Human Milk
May 7 at 6:06pm by Aileen
Michael Kramer, a professor of pediatrics at McGill University reported this week that breastfeeding raises children’s IQ and improves their academic performance later in childhood.
Their study evaluated children in 31 Belarusian hospitals and clinics. Half of the women were directly encouraged to breastfeed exclusively, the other half did things the ‘normal’ way (for Belorussia). Six and a half years later the children’s IQs were tested and their teachers submitted academic performance ratings. Scores on both were significantly higher for the children of women encouraged to breastfeed, though there is no indication that the researchers confirmed how many of those mothers actually did breastfeed or for how long.
“Our study provides the strongest evidence to date that prolonged and exclusive breastfeeding makes kids smarter,” Kramer said.
Read the rest of this entry »
The Hindu Goddess Baby
Apr 9 at 11:11pm by Aileen
For something different and profound, consider the case of a baby girl named Lali born near New Delhi, India on March 11. She has a rare birth defect called diprosopus that gave her two faces on one head. ABC News reported that the resident medical officer of the Saifi Hospital where Lali was born has thus far been unsuccessful in his attempts to convince the parents to allow CT scans or MRI to determine whether there are duplicated internal organs or invisible, life threatening deformities that might be corrected by surgery.
Most babies with this condition are stillborn or die shortly after birth, but Lali so far has shown no breathing or digestion difficulties, both mouths are being fed. She was born normally and left the hospital with her mother 8 hours after birth.
This condition is not technically a case of cojoined twinning, where a single embryo duplicates and does not completely separate. Rather, it is due to malfunctioning in the developing embryo of a single protein called Sonic hedgehog homolog [SHH]. SHH protein governs the width of the face and features, and governs proper development of the brain and spinal cord via a signaling cascade.
50 Weird Science Tidbits - 3
Feb 13 at 6:06pm by Aileen
Part 3: Items 21-30
Getting us past the halfway point in this series of things odd and quite possibly unknown, I’m going to go with some odd and interesting plant and animal facts, including an in-development “designer” breed of cat that just might steal my heart away from Maine Coons…
21. Did Tom Sawyer know these were under the raft?
These 7-foot, 220-pound Mississippi paddlefish are among the world’s biggest freshwater animals. Kin to sturgeon, they’re popular sources of meat and roe for caviar.
22. Designer Way to Help Endangered Tigers
Meet the Toyger! Breeding programs began in the 1980s to develop a breed of house cat that strongly resembles the mightiest of big cats. In 1993 Toygers were first registered with the International Cat Association [TICA], and now boasts grand champions. Must. Have. One…
Read the rest of this entry »
It’s Deja Vu All Over Again!
Jan 30 at 11:11pm by Aileen
Deep Brain Stimulation in Hypothalamus Triggers Deja Vu in Patient
A Neuroscience team in Canada tried an experimental treatment for a patient with morbid obesity a variety of treatments failed to control. They were stimulating potential appetite suppressing sites in his brain’s hypothalamus via implanted electrodes when he suddenly had a strong feeling of deja vu.
The ‘live’ memory recurred under double-blind restimulation. An arched bundle of fibers in the hypothalamus called the fornix was shown to drive temporal lobe and hippocampus activity, important parts of the brain’s memory circuitry.
This is a fascinating article, a sure eye-catcher for any of us who have ever experienced a strong sense of deja vu. Yet what it describes doesn’t sound much like deja vu to me, per my own experience and the general understanding of the phenomenon among most people I know.
Deja vu isn’t a dim memory that suddenly presents itself “as if” we’re there right now. It’s the sudden realization that what’s happening right now is something we’ve experienced before. I’ve had it so strongly that I knew what people were going to say and do before they said and did it!
So I have to wonder if perhaps the neuroscientists don’t have a clear understanding of the phenomenon, or the patient didn’t know the difference between reliving an old memory and remembering the present, or the writer of the press release didn’t know what the term refers to. I’m leaning toward the last possibility, since the actual quotations of the researchers speak of memory, not deja vu. Yet another terminology confusion in the science press, but definitely an interesting finding!
BERT and ERNI Play Important Roles in CNS Development
Jan 10 at 10:10pm by Aileen
…and you thought those silly Muppets were just silly!
With the melodic strains of Ernie’s Greatest Hit “Rubber Ducky” echoing my head, fans will be delighted to know that the dynamic duo created by Jim Henson and Frank Oz in 1969 as stars of the famous Sesame Street educational program have even more to do with brain development that originally thought!
Research published in the January 10 online issue of PLoS Biology reports A Mechanism Regulating the Onset of Sox2 Expression in the Embryonic Neural Plate has been discovered.
Chimps Beat Humans in Numbers Recall Video Game
Dec 5 at 5:05pm by Aileen
Tetsuro Matsuzawa of Kyoto University has once again embarrassed humans by testing chimpanzees against human adults on ‘working memory’. The chimps consistently beat college students in a computer game of remembering numbers, using the same test for both the chimps and the students. As Matsuzawa said…
“No one can imagine that chimpanzees — young chimpanzees at the age of 5 — have a better performance in a memory task than humans,” he said. “Here we show for the first time that young chimpanzees have an extraordinary working memory capability for numerical recollection — better than that of human adults tested in the same apparatus, following the same procedure.”
The research was published in the journal Current Biology.
Links:
Newsweek: Young chimp beats college students
Chimps top humans in numerical memory
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