News this week from the rarified realm of science research is both interesting and far-reaching. And no, by far-reaching I’m not talking about discovery that the planet Saturn has a huge, invisible ring nobody noticed before.

In the field of physics, some may have heard of Paul Dirac’s postulated magnetic monopoles – the quantum of the magnetic force, with a single pole instead of two. Dirac postulated that these must exist, and led to his famous ‘strings’ (which eventually led to some current GUT models). But nobody has ever actually ‘seen’ a monopole, so it’s been an open question of whether such beasties exist. Now, an NIST research team believe they’ve found the next best thing, monopoles the size of molecules!

They of course aren’t real monopoles, but apparently behave the same predicted way. Thus these synthetic compounds could allow scientists to do further research in the lab rather than just on paper napkins. They will be testing monopole predictions with these spin ice molecules, such as whether the postulated particles obey Coulomb’s Law. Stay tuned, this could get fascinating quickly!

Next up is a study about the ubiquitous BPA body burdens 93% of us carry around these days. BPA is a common chemical found in some plastics and epoxy resins. A paper published in Environmental Health Perspectives this week from researchers at Simon Fraser University, UNC-CH and Cincinnati Children’s Hospital linked prenatal BPA exposure to unusually aggressive, hyperactive behavior in 2-year old girls.

Neurodevelopmental disorders – ADD, ADHD, the Autism spectrum, etc. – have been most prevalent in young boys, who represent some 80% of the diagnoses. Further research on this environmental contaminant should be watched, as if the connection is solid, we can expect more and more young girls to suffer the same sorts of problems. BPA has also been linked to fertility problems, growth retardation and learning disorders as well as permanent changes to DNA in mice.

Speaking of Autism’s spectrum of neurodevelopmental disorders, researchers from MIT and the Center for Human Genetic Research at Massachusetts General Hospital have discovered that a single letter change in DNA may be indicative of Autism. This is known as a Single Nucleotide Polymorphism [SNP], and researchers tied it to chromosomes 5, 6, 20. The gene on chromosome 5 is associated with neuron development and autistic children showed lower expression.

This is just one piece of what researchers expect is a highly complex genetic puzzle, but it might lead to tests that can identify those at risk of producing autistic children, and identifying it in children very early. It also could help lead to specific treatments in the future. Progress is being made at last in dealing with this spectrum as a real medical condition and not just an indicator of lousy parenting skills. Which has been one of the most hurtful urban myths ever propagated by people who had no idea what they were talking about. That some of them were psychologists and physicians is sad, so we can all be thankful that some real answers are coming in.

If your Mama was anything like mine, you no doubt grew up with the constant admonition that “you are what you eat.” And despite the silly position of the AMA back in the early 1980s that there was no evidence to support the idea that diet has any direct relationship with health, almost all mothers know better. Thus it’s not entirely unexpected that medical science should be learning about the many ways that diet does indeed affect health, but it is welcome to wise Moms everywhere.

First up, a paper published in the journal Science by a research team at the University of Wisconsin demonstrates that simply reducing the amount of food eaten works to blunt the effects of aging and significantly delay onset of age-relatted conditions like cancer, diabetes, heart disease and brain atrophy. The research was conducted over 20 years on Rhesus monkeys at the National Primate Research Center at UW-Madison.

Conclusion? A restricted calorie diet will help you live longer and stay healthier.

The American Dietetic Association has also released an updated position paper on vegetarian diets that concludes a well-planned meatless diet is both healthful and nutritionally adequate and can help prevent or even treat chronic conditions like diabetes, obesity, cancer and heart disease.

Vegetarian diets have long been associated with lower blood cholesterol levels, lower risk of heart disease, lower blood pressure and reduced risk of type 2 diabetes. Because such diets are low-fat and generally provide more vitamins and minerals than a meat-based diet, the ADA has concluded that a meatless diet is appropriate for all stages of the human life cycle, including pregnancy, lactation, infancy and for athletes.

With ever increasing evidence that fewer calories, less meat and more fruits and vegetables can lead to a longer and healthier life, the number of vegetarians or semi-vegetarians among the population is expected to increase significantly over the next decade. Perhaps the most important take-away lesson from the evidence and research is that indulging in high-calorie processed foods and fatty meats to the point where a majority of the population weighs twice what they should weigh causes a huge chunk of the medical issues people suffer in the U.S.

In the meantime, the mortality rate of this flu, while initially high in the Mexico City area, has fallen overall to around 2% or less, in line with annual deaths during flu season. Those who contract the virus are still those generally considered to be in the healthiest range of the population. On the vaccine development front there have been several developments since the 2009 Swine Flu epidemic began:

On April 29 vaccine researchers at St. Louis University announced that they’d accomplished the first step in developing a universal vaccine against pandemic influenza. To accomplish this the researchers used proteins (engineered a ‘bug’ that produced said proteins from genetic sequences coding for them) from both A and B influenza strains. The vaccine introduces those proteins so the body can engineer antibodies specific to them. More testing is needed, they say, before the vaccine is ready for prime time.

On May 1 Juergen A. Richt, a pathobiologist at Kansas State University’s college of veterinary medicine released findings that the current lineage of H1N1 Swine Flu is a descendant of the 1918 strain that killed more than 20 million people worldwide. For the study Richt and colleagues from Canada, USDA and Mount Sinai engineered their ‘bug’ in a biosafety-level-4 lab (like the one at UT-Austin) at the National Centre for Foreign Animal Disease in Canada using elements from both the 1918 virus and a 1930 descendent of that virus.

On May 22 researchers at the University of Pittsburgh’s Center for Vaccine Research announced that they’d evoked a robust immune response with a vaccine made of virus-like particles [VLPs], which are just the protein coats of actual viruses without any genes inside. This approach, which like other approaches involves genetic manipulation to produce the “hollow” virus shells, may work better than attenuated virus vaccines. The new vaccine for Human Papilloma Virus is a VLP.

And finally, on June 4 Genetic Engineering and Biotechnology News reported that scientists around the world are accelerating efforts to develop an effective vaccine against the current Chimera strain. This is ‘news’ in the GE/biotech community because genetic manipulation is standard operating procedure in the development of influenza vaccines, of any type – live, attenuated, killed and dissociated or VLP. Step #1 is to engineer your Chimera.

No matter how the Chimera came to be, Bellerophon is engineered very much on purpose. I personally like the idea of the VLP vaccine, as it ONLY has coat proteins and it excites a more robust immune response to those than to dissociated coat proteins. The robust response is to the form of the viral shell. Even better, if these beasties get out in an ‘oops’ it won’t kill anybody – it’ll just immunize ‘em. Let’s all hope one of these is available come September.

Well, I’ve got to admit this much-touted development in the world of medical research took me somewhat by surprise. Mostly because it caused me to stop eating my grilled cheese sandwich mid-bite to wonder “Huh? Why in the world would they do that?”

Seems this week’s Nature is reporting that researchers in Japan have managed to genetically engineer the green fluorescent protein gene into primates – specifically marmosets. Yes, these endearingly cute little monkeys have been engineered to express the gene in their hair roots, skin and blood, all of which glow green under UV light sources.

Now, I can understand why tropical fish aficionados might want several tetras of each color (they’ve got several now) in their aquarium to impress friends, neighbors and potential mates, but glowing green marmosets? You’ve got to have a primate license to own any kind of monkey or ape! The researchers responsible for this development say that this feat of genetic engineering could lead to monkeys being bred with genetic changes that would make them good animal models of human diseases.

Researchers have been breeding genetically engineered mice for decades to exhibit specific genetically influenced disease conditions so they can work on treatments and cures, but rodents aren’t close enough to humans on the evolutionary tree to be all that useful for the purpose. Primates would, they contend, be much better models because they actually are close to humans genomically speaking. If a team believes it has discovered a particular gene that causes something like Parkinson’s Disease or Alzheimers or ALS or such, they could engineer a line of monkeys that carry the defect – thus suffer the disease – so researchers can play with various methods of treatment that might someday be effective for people who suffer the disease.

Transgenic primates have been created before, but have never managed to pass the engineering on to their offspring. This means “lines” of, say, Parkinson’s monkeys haven’t proved out.

The development is causing some concern among animal rights activists and anti-vivisectionists who object to creating populations of genetically diseased primates exclusively so they can serve as the subjects for painful (and often fatal) experiments. The new development will open the ethical debates that must accompany animal-based research, so perhaps will be a good thing.

And what of these glow in the dark marmosets? Well, humans that glow in the dark generally don’t get that trait from jellyfish genes, so these little monkeys aren’t actually useful for medical research beyond ‘the usual’ medical research performed on little monkeys. I figure they’ll start showing up at high end pet shops along with those multi-colored glow in the dark fish, a curiosity for the rich and bored. Those clever Japanese!

Links:

Glowing green monkeys set ‘dangerous precedent’
‘Glowing’ Transgenic Monkeys Carry Green Fluorescent Protein Gene

If your family managed to get through this year’s flu season intact, you’re probably considering yourself very lucky. The A strains claim tens of thousands of lives every year, while hundreds of thousands of people who get infected manage to bounce right back in a week or two. Researchers at the Helmholtz Center for Infection Research in Germany has conducted experiments using 7 strains of genetically identical mice that led the somewhat surprising conclusion that very serious infection and death from influenza is primarily an autoimmune malfunction.

The research, published in the Public Library of Science [PLoS-One] on line, demonstrates that an excessive immune response to the virus is responsible for fatal outcomes of the disease in mice, and that this immune overreaction is genetically linked.

After infecting mice from the seven genetic lineages with identical strains the Influenza A virus, the researchers were surprised to discover very strong differences in the progression of the disease. In five of the seven mouse lineages the illness was quite mild, while in two the animals lost weight rapidly and died within just a few days.

“The mice die from their own immune defenses, which are actually supposed to protect them against the virus,” says Klaus Schughart, head of the Experimental Mouse Genetics research group. “The immune system produces too many messengers, which have a strong activating effect on the immune cells. These cells then kill tissue cells in the lungs that are infected with the virus. It appears that the animals have specific receptors on their cells that make them more receptive to a severe viral infection.”

If the results can be extended by further research to humans, it may be possible to identify people who are much more likely to die of influenza due to specific genetic makeup, so that protecting them during flu season can be made a priority. While certain at-risk populations are advised to get their flu shots annually – including doctors and nurses most likely to be exposed to the virus – identifying who among the at-risk populations is most likely to develop a hyperactive and potentially fatal autoimmune response could make better use of flu vaccine supplies by targeting them to the right people.

Links:

Why Some People Shake Off the Flu
Host Genetic Background Strongly Influences the Response to Influenza A Virus Infections

Researchers at the University of Manchester in England have discovered that the herpes simplex virus – the virus that causes cold sores – is a major cause of the beta amyloid protein plaques found in the brains of Alzheimer’s sufferers, suggesting new methods of treatment.

Cold Sore Virus Linked to Alzheimer’s Disease: New Treatment, or Even Vaccine Possible

A majority of people are infected with the herpes simplex virus, which remains in the peripheral nervous system for the life of the person, occasionally showing up to cause cold sores. It is treated, usually when the sores show up, with antiviral agents such as acyclovir, and outbreaks can often be shortened by taking L-Lysine amino acid supplements. The discovery of a connection between herpes simplex and the amyloid plaques of AD lends hope to the idea that Alzheimer’s may one day soon be treatable with antiviral drugs, or even that a vaccine could be developed against both the herpes infection and AD.

The research team examining plaques and neurofibrillary tangles from AD patients discovered that HSV1 viral DNA was found in 90% of those abnormal protein structures. The same team had previously found that HSV1 infection of nerve cells induces deposition of the plaques. Previous treatments for this dread disease of aging have focused on symptoms of the disease rather than any root causes. As the population ‘bump’ known as the “Baby Boom” generation ages, this discovery may help to prevent a great deal of suffering both for victims of the disease and their families.

The Manchester team hope to receive funding that will enable them to investigate in detail the effect of treating early Alzheimer’s patients with antiviral agents. The paper was published in the Journal of Pathology, Volume 217, entitled Herpes simplex virus type 1 DNA is located within Alzheimer’s disease amyloid plaques.

Scientists at the Alzheimer’s Disease Research Center at Washington University School of Medicine in St. Louis have found that some people who have the plaques in their brain associated with AD still manage to score well on tests of cognitive ability if they spent more years in school, and put their cognitive abilities to work on a regular basis. Those with less education, who may not regularly exercise their brains than better educated people, tend to display more symptoms of cognitive decline.

Strong Educatiion Blunts Effects of Alzheimer’s Disease -

“As expected, those whose brains showed little evidence of plaque buildup scored high on all the tests. But while most participants with high levels of brain plaque scored poorly on the tests, those who had done postgraduate work still scored well. Despite signs that Alzheimer’s might already be ravaging the brains of this subgroup, their cognitive abilities had not declined and they had not become demented.”

So get busy, all you aging Boomers! Now that the nation’s economy is tanking and the government’s printing enough money to deforest the Amazon basin [snark], it’s time to go back to school! Or just audit some courses that interest you. Or take some online courses, just for fun. Download that computerized Scrabble game, do crossword puzzles, join a book discussion clutch, whatever. I want to see you put the burn to that flabby brain, whip it into shape!

…and the payoff just might be that you keep more of your mind later in your life than you otherwise would!

I don’t know about you, but in my family there is an unfortunate tendency to develop serious headaches. Two sisters have suffered migraines since childhood, my daughter gets them too, and her son has fairly regular headaches that end up sending him to his bed in pain. Lots of people get headaches not quite so severe, and various headache remedies have become part of urban legend lore as well as accounting for billions of dollars’ worth of pharmaceutical company profits over the years.

Sometimes it’s not just a matter of “take two aspirin, call me in the morning.” Luckily, Stephanie over at the blog One Big Health Nut has researched a total of 23 Ways To Get Rid Of & Prevent Headaches. These have solid science behind them and links to demonstrate that, so it’s definitely a blog post worthy of checking out and keeping in your bookmarks if you or anyone in your family suffers from debilitating headaches.

I was gratified to see that our own long-time “family recipes” are indeed supported by good science. Such as drinking lots of water, dehydration being a cause of headaches. Limiting caffine and alcohol, eating regularly and staying away from fried foods too. The only thing missing that I would add to the list is one that Stephanie semi-includes. She advises that a paste of cinnamon and water applied to the brow and temples can help relieve headaches, and this is supported enough to use if you can. The same idea using hot pepper powder has worked well in my own family, the capsaicin stimulating scalp circulation. Which I presume is the method that works with cinnamon paste.

This very useful resource is excellent, so do keep it on file!

Please go to the ScienceDebate 2008 website, take a hard look at Obama’s answers for our future, and don’t forget to drop the crew a dime (or ten) on your way out. These folks have been hard at it since November of last year, and have gathered some very impressive institutional support. The future is important to all of us – and our children – and the future needs the very best science we can possibly field to meet it head-on.

1918 Flu Antibodies Resurrected from Elderly Survivors

Back in 2005 some researchers journeyed to the Alaskan permafrost to dig up some bodies of victims of the 1918 Spanish flu pandemic that killed 50-100 million people worldwide as World War 1 came to a close. They were able to recover the virus from these bodies because they have been frozen since burial.

Now researchers at Monroe Carell Jr. Children’s Hospital at Vanderbilt have recovered antibodies against this deadly flu virus from survivors of the pandemic. They collected blood samples from 32 survivors age 91 to 101, and found that all samples reacted to the virus – indicating that immunity has been preserved for 90 years. This represents the longest immune system ‘memory’ thus far observed.

The real test came when researchers at the CDC infected mice with the 1918 influenza and then administered the antibodies. Those receiving the lowest dose of antibodies died, all mice given the highest dose survived. The “extremely rare” B cells that produced the antibodies in all the survivors’ blood are some of “the most potent antibodies ever isolated against a virus,” and may prove invaluable against other viruses or for developing new antibodies against expected future pandemics.