New Hope for Alzheimer’s Patients?
Jul 21 at 6:06pm by Aileen
USPS Alzheimer’s Stamp
Rapid Alzheimer’s Improvement After New Immune-based Treatment
The open access journal BMC Neurology published research this week detailing some amazing results from the use of the anti-tumor necrosis factor-alpha [TNF-alpha] drug to treat symptoms of Alzheimer’s Disease from a novel immune system approach. Researchers documented improvement in language function within minutes of administering the drug, tending to confirm preliminary evidence that disrupted neural communication in Alzheimer’s patients may be reversible.
This is a very hopeful development, as are results from clinical drug trials in recent years slowing the progression of the disease in elderly patients as well as ongoing research into substances that may help clear the beta amyloid placques in the brain tissue, characteristic of the disease. As the Baby Boomer generation ages, it is estimated that up to 10 million of them will get this awful disease.
Some doctors are expressing concern about unduly raising hopes in patients and their families on these very early findings. Dr. Sam Gandy, chairman of the Alzheimer’s Association’s medical and science council, has expressed suspicion due to the private nature of the research because the lead researcher has a financial interest in the drug. It is hoped that other laboratories and scientists will be able to duplicate the results, but that more rigorous clinical work remains to be done.
UCLA associate professor of neurology John Ringman and colleagues have reported in the journal Neurology that there may be a way to detect Alzheimer’s even before symptoms appear by measuring the level of certain proteins in the blood and spinal fluid. These proteins are potentially useful biomarkers to identify and track progression of the disease before the patient shows any signs of deteriorating mental acuity.
The amount of suffering for the families of those 10 million people could be reduced drastically if there were effective treatments, so there is a good deal of public and private research ongoing. Hopefully when the Boomers reach an age where they have ready access to medical care via Medicare, diagnosis and treatment will be available to them.
Addicted To Your Baby’s Smile
Jul 8 at 3:03pm by Aileen
Most parents know very well how heart-warming their baby’s smile can be, to the point where just doing something silly to get that smile-fix becomes a regular way of life. I’ve heard all sorts of weird philosophies about baby smiles - “it’s just gas,” “they’ve got the intelligence of rats,” etc., etc., things that only non-parents would ever think of.
So it’s cool that researchers at the Baylor College of Medicine have finally demonstrated the addictive quality of baby smiles, as reported recently in the journal Pediatrics. Turns out that baby smiles actually ‘light up’ the reward centers of the human brain, particularly in Moms - it’s what they call a “Natural High.”
Baby’s Smile Is A Natural High
The researchers hope their work will help scientists understand the unique mother-infant bonding so critical for proper child development (and mothers’ mental health).
No doubt this is fine research, and it’s gratifying to know that science is actually looking at phenomena they could have known all along if they’d just asked a Mom. Oh, well. That famous scientific skepticism needs physical ‘proof’ of physical phenomena before it will believe anything most regular people know from direct empirical experience. Maybe they’ll now come up with a pill that mimics this high, which will no doubt be a big item on the black market for pharmaceuticals…
It’s Deja Vu All Over Again!
Jan 30 at 11:11pm by Aileen
Deep Brain Stimulation in Hypothalamus Triggers Deja Vu in Patient
A Neuroscience team in Canada tried an experimental treatment for a patient with morbid obesity a variety of treatments failed to control. They were stimulating potential appetite suppressing sites in his brain’s hypothalamus via implanted electrodes when he suddenly had a strong feeling of deja vu.
The ‘live’ memory recurred under double-blind restimulation. An arched bundle of fibers in the hypothalamus called the fornix was shown to drive temporal lobe and hippocampus activity, important parts of the brain’s memory circuitry.
This is a fascinating article, a sure eye-catcher for any of us who have ever experienced a strong sense of deja vu. Yet what it describes doesn’t sound much like deja vu to me, per my own experience and the general understanding of the phenomenon among most people I know.
Deja vu isn’t a dim memory that suddenly presents itself “as if” we’re there right now. It’s the sudden realization that what’s happening right now is something we’ve experienced before. I’ve had it so strongly that I knew what people were going to say and do before they said and did it!
So I have to wonder if perhaps the neuroscientists don’t have a clear understanding of the phenomenon, or the patient didn’t know the difference between reliving an old memory and remembering the present, or the writer of the press release didn’t know what the term refers to. I’m leaning toward the last possibility, since the actual quotations of the researchers speak of memory, not deja vu. Yet another terminology confusion in the science press, but definitely an interesting finding!
BERT and ERNI Play Important Roles in CNS Development
Jan 10 at 10:10pm by Aileen
…and you thought those silly Muppets were just silly!
With the melodic strains of Ernie’s Greatest Hit “Rubber Ducky” echoing my head, fans will be delighted to know that the dynamic duo created by Jim Henson and Frank Oz in 1969 as stars of the famous Sesame Street educational program have even more to do with brain development that originally thought!
Research published in the January 10 online issue of PLoS Biology reports A Mechanism Regulating the Onset of Sox2 Expression in the Embryonic Neural Plate has been discovered.
Objectively Measuring Subjective Pain
Nov 16 at 6:06pm by Aileen
Doctors involved in treating pain have long been stifled by the subjectivity of pain - relying on patients to rate their own pain, but having no objective way to measure how intense the pain really is. The journal Nature reported on November 14 that they have discovered a signal from the brain that does objectively correlate with the amount of pain a person is experiencing.
The researchers from Oxford University in Britain believe that the signal couldbe used to refine pain relief techniques, offering better treatment for people in pain. The signal is identified as low frequency brain waves emanating from two regions deep in the brain. The more pain being experienced, the longer the waves last.
“It is an objective measure that correlates with a subjective measure,” said Morten Kringelbach, head of the research team. They hope this signal could help refiine deep-brain stimulation for chronic pain management through the development of a stimulator that only kicks in when these low frequency signals begin.
The ability to treat chronic pain directly without the use of drugs that affect consciousness or depress general physiology would be a significant advancement in medical care, alleviating the suffering of millions of people every year.
Related Links:
Scientists create targeted pain management
Flotation tanks help reduce pain
American Academy of Pain Management
Resistance Is Futile…
Nov 1 at 5:05pm by Aileen
And Things Nature Does to Rattle Our Perceptions
Lots of interesting science reports lately about all things neurological, in brains and in our remote sensor neurons. First up is a surprising (or maybe not so surprising) finding by a researcher at the University of Hertfordshire - the harder we try to mentally suppress our thoughts and desires, the more we will indulge in the activity we’re trying to suppress.
Resistance to Thoughts of Chocolate is Futile
This research project dealt with something quite simple, chocolate. Which some say is addictive, but that’s a whole different area of research. Dr. Erskine of Hertfordshire divided 134 young (avg. age 22) people into two groups to investigate how our thinking affects our behaviors.
The participants were asked to try two brands of chocolate and answer questions about which they preferred and why. Then they were given two periods of thought verbalization where they were to talk about their thoughts while alone. On top of this they were told they must think about - or not think about - certain things. Including chocolate.
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