Science News Review

Resurrecting the 1918 Flu Pandemic

Aug 19 at 4:04pm by Aileen

…and the antibodies for survival

1918 Flu Antibodies Resurrected from Elderly Survivors

Back in 2005 some researchers journeyed to the Alaskan permafrost to dig up some bodies of victims of the 1918 Spanish flu pandemic that killed 50-100 million people worldwide as World War 1 came to a close. They were able to recover the virus from these bodies because they have been frozen since burial.

Now researchers at Monroe Carell Jr. Children’s Hospital at Vanderbilt have recovered antibodies against this deadly flu virus from survivors of the pandemic. They collected blood samples from 32 survivors age 91 to 101, and found that all samples reacted to the virus - indicating that immunity has been preserved for 90 years. This represents the longest immune system ‘memory’ thus far observed.

The real test came when researchers at the CDC infected mice with the 1918 influenza and then administered the antibodies. Those receiving the lowest dose of antibodies died, all mice given the highest dose survived. The “extremely rare” B cells that produced the antibodies in all the survivors’ blood are some of “the most potent antibodies ever isolated against a virus,” and may prove invaluable against other viruses or for developing new antibodies against expected future pandemics.